HbH is seen in which of the following conditions?
A. Deletion of 3 beta genes
B. Deletion of 3 alpha genes
C. Deletion of 4 beta genes
D. Deletion of 4 alpha genes

Correct answer : B. Deletion of 3 alpha genes

  • HbH is formed by 4 beta chains (tetramer of beta chains)
  • It is seen in alpha thalassemia with deletion of 3 alpha chains
  • It is precipitated as Heinz bodies within RBC’s
  • Deletion of 4 alpha chains results in formation of Hb Barts (gamma chain tetramer) and is incompatible with life
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