HbH – MCQ

HbH is seen in which of the following conditions?
A. Deletion of 3 beta genes
B. Deletion of 3 alpha genes
C. Deletion of 4 beta genes
D. Deletion of 4 alpha genes

Correct answer : B. Deletion of 3 alpha genes

  • HbH is formed by 4 beta chains (tetramer of beta chains)
  • It is seen in alpha thalassemia with deletion of 3 alpha chains
  • It is precipitated as Heinz bodies within RBC’s
  • Deletion of 4 alpha chains results in formation of Hb Barts (gamma chain tetramer) and is incompatible with life
One Comment

Add a Comment

Your email address will not be published. Comments will be displayed only after moderation.

Read previous post:
pathology mcq
Coagulation pathway – MCQ

All are true about coagulation pathway except? A. Intrinsic pathway can be activated in vitro B. Calcium is necessary for...

Close