Hormones secreted by the kidney

The kidney secretes a variety of hormones. They are:

  • Erythropoietin
    • It is produced by the peritubular capillary endothelial cells in response to hypoxia
    • It acts on the bone marrow to stimulate erythropoiesis
  • 1,25-Dihydroxycholecalciferol
    • It is also known as calcitriol – the active form of Vitamin D
    • It is formed by hydroxylation of 25-hydroxycholecalciferol by the enzyme 25-hydroxyvitamin D3 1-alpha-hydroxylase located in the proximal tubules of the nephron
    • The activity of the enzyme is under the control of PTH (Parathyroid hormone)
    • It stimulates calcium absorption from the intestine and reabsorption of calcium and phosphate from the kidneys
  • Renin
    • It is secreted by the juxtaglomerular apparatus of the kidney
    • It is secreted in response to a decrease in arterial blood pressure or sodium chloride content in blood
    • It plays an important role in electrolyte balance by mediating the conversion of angiotensinogen to angiotensin I

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