Hyaline change is a homogenous glassy pink appearance in the histological sections stained with hematoxylin and eosin. It can be due to intracellular accumulation of certain substances as in Russel bodies (multiple myeloma), Mallory bodies (alcoholic liver disease), re-absorption droplets (kidney). Extra cellular hyaline change can be seen in walls of the arterioles in long standing hypertension and diabetes mellitus. This is due to extravasated plasma protein and deposition of basement membrane material.
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