Mechanism of action of fibrates

derivatives of fibric acid (isobutyric acid)
activate Peroxisome Proliferator Activated Receptor alpha (PPAR) – a gene transcription regulating receptor present in liver, fat and muscles

Activation of PPAR alpha results in:

increased synthesis of lipoprotein lipase – hydrolyse triglycerides – decrease circulating TG’s
increased expression of LDL receptor in liver – mainly with II generation fibrates
increased fatty acid oxidation
decrease TG synthesis in liver
reduce circulating free fatty acids

Outcome:

decrease TG 20-50%
decrease LDL 10-15%
increase HDL 10-15%

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