Medicine – MCQ 116 – A patient aged 65 years, is diagnosed to have severe aplastic anemia

A patient aged 65 years, is diagnosed to have severe aplastic anemia. HLA compatible sibling is available. The best option of treatment is;
a) Anti thymocyte globulin followed by cyclosporine
b) A conventional bone marrow transplantation from the HLA identical sibling
c) A non-myeloablative bone marrow transplantation from the HLA identical sibling
d) Cyclosporine

Correct answer : a) Anti thymocyte globulin followed by cyclosporine

Treatment of choice in an elderly individual with severe aplastic anemia is immunosuppression – Anti thymocyte globulin followed by cyclosporine. Bone marrow transplantation is tried only in young adults.

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