Which of the following monoclonal antibody is used in the treatment of asthma?
Correct answer: A. Mepolizumab
Mepolizumab is a monoclonal antibody against interleukin 5 used in the maintenance treatment in severe asthma. It is the first FDA approved drug that targets interleukin 5. IL-5 regulates the function of eosinophils.
Bevacizumab is a monoclonal antibody that inhibits vascular endothelial growth factor. It is used in the treatment of various neoplasms like lung cancer, glioblastoma, renal cell carcinoma and other conditions like diabetic retinopathy and age related macular degeneration.
Ocrelizumab is an anti CD-20 monoclonal antibody. It was approved by the FDA in 2017 for the treatment of multiple sclerosis.
Certolizumab is a monoclonal antibody that binds to tumour necrosis factor alpha. It is used in the treatment of rheumatoid arthritis and Crohn’s disease.