Most potent fluoroquinolone against Mycobacterium leprae? – Pharmacology MCQ

Most potent fluoroquinolone against Mycobacterium leprae is?
A. Levofloxacin
B. Ofloxacin
C. Moxifloxacin
D. Ciprofloxacin

Correct answer : C. Moxifloxacin

Photomicrograph of Mycobacterium leprae – small brick red rods found in clusters

Ciprofloxacin has poor activity against Mycobacterium leprae.
Ofloxacin, Pefloxacin, Moxifloxacin and Sparfloxacin have high level of activity against Mycobacterium leprae.
Among them, Moxifloxacin is the most potent.

Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p782.
Image credits: CDC Public Health Image Library (PHIL) #2123. https://en.wikipedia.org/wiki/File:Mycobacterium_leprae.jpeg

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