Most potent fluoroquinolone against Mycobacterium leprae? – Pharmacology MCQ

Most potent fluoroquinolone against Mycobacterium leprae is?
A. Levofloxacin
B. Ofloxacin
C. Moxifloxacin
D. Ciprofloxacin

Correct answer : C. Moxifloxacin

Photomicrograph of Mycobacterium leprae – small brick red rods found in clusters

• Ciprofloxacin has poor activity against Mycobacterium leprae.
• Ofloxacin, Pefloxacin, Moxifloxacin and Sparfloxacin have high level of activity against Mycobacterium leprae.
• Among them, Moxifloxacin is the most potent.

Ref: Essentials of Medical Pharmacology, K D Tripathi, 7th ed, p782.
Image credits: CDC Public Health Image Library (PHIL) #2123. https://en.wikipedia.org/wiki/File:Mycobacterium_leprae.jpeg