A 50-year-old man has had gradually progressive weakness of the hands during the past year. Physical examination shows atrophy of the
forearm muscles, fasciculations of the muscles of the chest and upper extremities, and hyperreflexia of the lower extremities. A
Babinski sign is present bilaterally. Sensation is intact. Which of the following is the most likely diagnosis?
(A) Amyotrophic lateral sclerosis
(B) Dementia, Alzheimer type
(C) Guillain-Barré syndrome
(D) Multiple cerebral infarcts
(E) Multiple sclerosis
Correct answer : (A) Amyotrophic lateral sclerosis
The patient has LMN (lower motor neuron) signs in upper limb and UMN (upper motor neuron) signs in lower limb which is seen in Amyotrophic lateral sclerosis.