A 46-year-old woman receives a non−Tlymphocyte-depleted, allogeneic bone marrow transplant from a matched, unrelated donor. Immunosuppressive therapy with cyclosporine is started. One month later, she has fever. Cytolytic destruction of the skin, gastrointestinal tract, and liver is seen, with associated dermatitis, enteritis, and hepatitis. Which of the following best explains these findings?
(A) C3b deposition
(B) Cytomegalovirus infection
(C) Graft-versus-host disease
(D) Tolerance induction
(E) Type I (immediate) hypersensitivity
Correct answer : (C) Graft-versus-host disease