Paediatrics – MCQ 50 – Gene expression
The process underlying differences in expression of a gene according to which parent has transmitted is called:
A. Anticipation
B. Mosaicism
C. Non penetrance
D. Genomic imprinting
Correct answer : D. Genomic imprinting
In genomic imprinting, a gene / group of genes on the paternal or maternal chromosome is selectively inactivated. The functional allele will be provided by the counterpart.
Example:
- Angelman syndrome – deletion of maternal gene
- Prader Willi syndrome – deletion of paternal gene