Paraproteinemia – Definition

  • Paraproteinemia refers to increased amounts of a singly type of monoclonal gammaglobulins in the blood
  • It indicates an underlying immunoproliferative disorder


  • Depending on the type of monoclonal gammaglobulins found in blood, paraproteinemias are of 3 types
    • Light chain disease (light chain only present)
    • Heavy chain disease (heavy chain only present)
    • Full immunoglobulins (light chain : heavy chain ratio may vary)

Alternate name – Monoclonal gammopathy

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MGUS – Acronym

MGUS stands for: Monoclonal Gammopathy of Undetermined Significance