Pathology – MCQ 73

Which of the following statement is not true?
A. Patients with lgD myeloma may present with no evident M-spike on serum electrophoresis
B. A diagnosis of plasma cell leukemia can be made if circulating peripheral blood plasmablasts comprise 14% of peripheral blood white cells in a patient with white blood cell count of 1 * 10^9/L and platelet count of 88 * 10^9/L
C. ln smoldering myeloma plasma cells constitute 10-30% of total bone marrow cellularity
D. ln a patient with multiple myeloma, a monoclonal light chain may be detected in both serum and urine

Correct answer : B. A diagnosis of plasma cell leukemia can be made if circulating peripheral blood plasmablasts comprise 14% of peripheral blood white cells in a patient with white blood cell count of 1 * 10^9/L and platelet count of 88 * 10^9/L

To be considered as plasma cell leukemia, plasma cells should constitute more than 20% of peripheral blood WBC’s. (Here it is only 14%)

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