Pauci-immune rapidly progressive glomerulonephritis – Pathology MCQ

Which is a pauci-immune rapidly progressive glomerulonephritis?
A. Lupus nephritis
B. Microscopic polyangiitis
C. IgA nephropathy
D. Goodpasture syndrome

Correct answer : B. Microscopic polyangiitis

Rapidly progressive glomerulonephritis - HistopathologyRapidly progressive glomerulonephritis – PAS stain

  • Rapidly progressive glomerulonephritis can be of 3 types :
    • Type I (Anti-GBM antibody)
    • Type II (Immune complex)
    • Type III (pauci-immune)
  • Goodpasture syndrome is an example of Type I rapidly progressive glomerulonephritis.
  • IgA nephropathy and Lupus nephritis are examples of type II.
  • Microscopic polyangiitis is classified as Type III (pauci-immune).

Ref: Robbins & Cotran, Pathologic basis of disease, South Asia edition, Vol 2, p912.
Image credits: Nephron. Licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. https://en.wikipedia.org/wiki/File:Crescentic_glomerulonephritis_-_high_mag.jpg

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