Pauci-immune rapidly progressive glomerulonephritis – Pathology MCQ

Which is a pauci-immune rapidly progressive glomerulonephritis?
A. Lupus nephritis
B. Microscopic polyangiitis
C. IgA nephropathy
D. Goodpasture syndrome

Correct answer : B. Microscopic polyangiitis

Rapidly progressive glomerulonephritis – PAS stain

• Rapidly progressive glomerulonephritis can be of 3 types :
  • Type I (Anti-GBM antibody)
  • Type II (Immune complex)
  • Type III (pauci-immune)
• Goodpasture syndrome is an example of Type I rapidly progressive glomerulonephritis.
• IgA nephropathy and Lupus nephritis are examples of type II.
• Microscopic polyangiitis is classified as Type III (pauci-immune).

Ref: Robbins & Cotran, Pathologic basis of disease, South Asia edition, Vol 2, p912.
Image credits: Nephron. Licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. https://en.wikipedia.org/wiki/File:Crescentic_glomerulonephritis_-_high_mag.jpg