Pharmacology – MCQ 12 – The following drugs are used in obesity except?

The following drugs are used in obesity except?
A. Orlistat
B. Sibutaramine
C. Olestra
D. Neuropeptide Y Agonist

Correct answer : D. Neuropeptide Y Agonist

Older antiobesity drugs act by inhibiting noradrenaline or serotonin reuptake. Newer ones have various mechanisms.

• Older generation agents
  • Noradrenergic agents (influence appetite center)
    • Phentermine
    • Mazindol
  • Serotonergic agents (influence satiety center)
    • Fenfluramine
    • Dexenfluramine
  • Noradrenergic / Serotonergic agents (combined action)
    • Sibutramine
• Newer agents
  • Orlistat – Inhibits gastric and pancreatic lipase – digestion and absorption of triglycerides is impaired
  • Olestra – Suprose polyester which can replace fat as a cooking medium
  • Leptin analogues
  • Neuropeptide Y antagonist
  • Beta 3 adrenergic agonists