Pharmacology – MCQ 131 – Dose reduction in low creatinine clearance
Which of the following fluoroquinolones does not require dose adjustment in a patient with creatinine clearance of < 50mg/min?
A. Ciprofloxacin
B. Trovafloxacin
C. Lomefloxacin
D. Sparfloxacin
Correct answer : B. Trovafloxacin
Fluoroquinolones that are excreted mainly by non renal mechanisms:
- Pefloxacin
- Trovafloxacin
- Grepofloxacin
- Nalidixic acid