Pharmacology – MCQ 39 – Mechanism of action of Imatinib in CML

Imatinib used in CML acts by
a) inhibiting Bcr/abl translocation via tyrosine kinase
b) Blocking the action of P-glycoprotein
c) Competitive inhibition of ATP binding site of ABL kinase
d) C-kit kinase inhibition

Correct answer : c) Competitive inhibition of ATP binding site of ABL kinase

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