Physiology MCQ – Thrombin inhibitor

Which of the following inhibits thrombin activity?

A. Heparin cofactor II

B. Alpha 2 antitrypsin

C. Chymotrypsin

D. Alpha 2 macroglobulin

 

Correct answer : D. Alpha 2 macroglobulin

 

Thrombin inhibitors in plasma are:

  • Antithrombin III (75% of total activity)
  • Alpha 2 macroglobulin
  • Heparin cofactor II (minor)
  • Alpha 1 antitrypsin (minor)

So both A and D are correct, but the best answer is D (Alpha 2 macroglobulin).

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