Kayser Fleischer Ring is seen in what proportion of Wilson’s disease patients with neurologic features?
Correct answer: D. 100%
- Kayser Fleischer Ring is the result of copper deposition in Descemet’s membrane around the cornea.
- It appears as a grayish ring at the limbus.
- It is seen in 80% of patients with Wilson’s disease presenting with hepatic dysfunction and in 100% of those with neurologic features.
- Hence slit lamp examination is essential for diagnosis of Wilson’s disease presenting with neurologic abnormalities.
- Usual neurologic manifestations in Wilson’s disease include tremor that has wing beating character in advanced stages, rigidity, dystonia, dysarthria and dysphagia.
- History of psychiatric disturbances like depression and mood swings are seen in more than half of those with neurologic features.