Protein misfolding disorders – Biochemistry MCQ
Which of the following is not a protein misfolding disorder?
A. Tuberculosis
B. Creutzfeldt Jakob disease
C. Alzheimer’s disease
D. Cystic fibrosis
Correct answer : A. Tuberculosis
- Tuberculosis is not a disorder of protein misfolding
A beta amyloid deposits in the cerebral cortex of a patient with Alzheimer’s disease – Immunohistochemistry photomicrograph.
Protein misfolding disorders
- Protein misfolding disorders, also known as proteopathies are conditions in which some proteins become structurally abnormal and impair the function of cells and tissues.
- Protein folding is abnormal and they fail to perform normally and may even gain toxic effects.
- e.g. Alzheimer’s disease (beta amyloid peptide), Creutzfeldt Jakob disease (prion disease), Cystic fibrosis (CFTR).
