Regarding somatomedin, which is true? – Physiology MCQ

Regarding somatomedin, which is true?
A. Reduced glucose oxidation in fat
B. Increases chondrogenesis
C. Activity is increased in protein deficiency
D. Activity is increased by glucocorticoids

Correct answer : B. Increases chondrogenesis

Insulin-like growth factor 1 (somatomedin C)Structure of somatomedin C (Insulin-like growth factor 1)

  • Somatomedin increases glucose oxidation in fat.
  • Activity of somatomedin is reduced by protein deficiency and glucocorticoids.
  • It has insulin like effect on tissues and causes lipolysis and increased glucose and amino acid transport by muscle.

Ref: Textbook of Physiology, A K Jain, 3rd edition, Volume 2, page 670.
Image credits: Author: Emw. Licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. https://en.wikipedia.org/wiki/File:Protein_IGF1_PDB_1bqt.png

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