Serotonin syndrome – MCQ

All of the following statements about serotonin syndrome are true, except:
A. lt is not an idiosyncratic reaction
B. Can be caused by SSRI
C. Dantrolene is the drug of choice
D. Associated with hyperthermia and hypertension

Correct answer : C. Dantrolene is the drug of choice

Dantrolene is the drug of choice for malignant hyperthermia
Serotonin syndrome is a dose related phenomenon and is not idiosyncratic
It is treated with benzodiazepines, muscle relaxation, endotracheal intubation and mechanical ventilation
Dantrolene can be used in severe serotonin syndrome with malignant hyperthermia
Drug of choice in mild / moderate serotonin syndrome – cyproheptadine – an antihistaminic with antiserotonergic action

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