Serotonin syndrome – MCQ

All of the following statements about serotonin syndrome are true, except:
A. lt is not an idiosyncratic reaction
B. Can be caused by SSRI
C. Dantrolene is the drug of choice
D. Associated with hyperthermia and hypertension

Correct answer : C. Dantrolene is the drug of choice

  • Dantrolene is the drug of choice for malignant hyperthermia
  • Serotonin syndrome is a dose related phenomenon and is not idiosyncratic
  • It is treated with benzodiazepines, muscle relaxation, endotracheal intubation and mechanical ventilation
  • Dantrolene can be used in severe serotonin syndrome with malignant hyperthermia
  • Drug of choice in mild / moderate serotonin syndrome – cyproheptadine – an antihistaminic with antiserotonergic action

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