Severe muscle weakness is seen in? – Medicine MCQ

Severe muscle weakness is seen in?
A. Cori disease
B. Andersen disease
C. McArdle disease
D. Tarui disease

Correct answer : B. Andersen disease

Glycogen storage disease – liver biopsy

• Andersen disease is a type 4 glycogen storage disease.
• It occurs due to deficiency of brancher enzyme.
• It usually presents in infancy with severe muscle weakness.
• Cirrhosis can also occur.

Ref: Davidson’s Principles and Practice of Medicine, 22nd edition, p450
Image credits: Nephron. Licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. https://commons.wikimedia.org/wiki/File:Glycogen_storage_disease_in_liver_-_very_high_mag.jpg