Sewage worker with fever and jaundice – SPM MCQ

A sewage worker with fever and jaundice presented to the emergency department. Lab investigations revealed increased blood urea nitrogen and serum creatinine – indicative of renal failure. Which of the following antibiotics is preferred in this patient?

A. Erythromycin
B. Doxycycline
C. Penicillin G
D. Ciprofloxacin

Correct answer : C. Penicillin G

• The history of fever and jaundice in a sewage worker with features of renal failure is suggestive of Weil’s disease
• Intravenous penicillin G is the preferred antibiotic for treatment of Weil’s disease
• Erythromycin can be used as an alternative
• In mild cases of leptospirosis, oral therapy with ampicillin / tetracycline is given
• Doxycycline is used for prophylaxis against leptospirosis