Sewage worker with fever and jaundice – SPM MCQ

A sewage worker with fever and jaundice presented to the emergency department. Lab investigations revealed increased blood urea nitrogen and serum creatinine – indicative of renal failure. Which of the following antibiotics is preferred in this patient?

A. Erythromycin
B. Doxycycline
C. Penicillin G
D. Ciprofloxacin

Correct answer : C. Penicillin G

  • The history of fever and jaundice in a sewage worker with features of renal failure is suggestive of Weil’s disease
  • Intravenous penicillin G is the preferred antibiotic for treatment of Weil’s disease
  • Erythromycin can be used as an alternative
  • In mild cases of leptospirosis, oral therapy with ampicillin / tetracycline is given
  • Doxycycline is used for prophylaxis against leptospirosis
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