Torsemide
It is loop diuretic acting on Na+ K+ 2Cl- Co-transporter in thick ascending limb of loop of Henle.
Torsemide vs Frusemide
- 3 times more potent
- better oral bioavailability
- absorbed more rapidly when given orally
- longer T1/2 (3.5 hrs)
- longer duration of action (4-8 hrs)
Indications
- Edema
- Hypertension
Dose
- 2.5-5mg OD in hypertension
- 5-20mg/day in edema
- upto 100mg BD in renal failure