Which is a true statement regarding inhibin? – Physiology MCQ

Which is a true statement regarding inhibin?
A. Increases the secretion of GnRH.
B. Molecular weight is between 5000 and 10,000.
C. It is secreted by hypothalamus.
D. It is a glycoprotein.

Correct answer : D. It is a glycoprotein.

• Inhibin is secreted by the sertoli cells in males and by the granulosa cells in females.
• It inhibits the secretion of Gonadotrophin Releasing Hormone.
• It is a glycoprotein with molecular weight between 10,000 and 30,000.
• It has potent inhibitory feedback effect on the anterior pituitary gland which in turn provides negative feedback mechanism for the control of spermatogenesis.

Ref: Textbook of Medical Physiology, Guyton and Hall, 11th edition, page 1007.