Why is warfarin given at night?

Collection of Medicine MCQs (Cardiovascular system) for medical students. Concept based MCQs with detailed explanations which help students to gain valuable insights and gain an edge in competitive examinations. More than just answering MCQs, the explanations will improve the knowledge and understanding about the conditions discussed. Also useful for MD students who are preparing for Superspeciality entrance examinations. Medicine MCQs - Cardiovascular System Kindle Edition: Click Here for a Preview. Comments and suggestions are most welcome.

Warfarin exerts its anticoagulant action by interfering with the vitamin K mediated synthesis of clotting factors in the liver. Hepatic synthetic function is maximum at night. So warfarin has maximum action when it is given at night. Other drugs which block the hepatic synthetic function (eg: statins are used to block cholesterol synthesis) are also best given at night time.

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