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[22 Dec 2012 | No Comment | ]

Important drugs which precipitate lithium toxicity are:

Diuretics
ACE inhibitors
Angiotensin receptor blockers
NSAIDS
Antibiotics like tetracycline

Pharmacology »

[22 Dec 2012 | No Comment | ]

The drugs associated with pyridoxine deficiency are:

INH (isoniazid)
Oral contraceptive pills
Penicillamine
Hydralazine
Cycloserine

Pharmacology »

[13 May 2012 | No Comment | ]

Disulfiram causes an acute reaction following intake of alcohol and is used for treatment of alcoholism (deterrent therapy). Some drugs produce disulfiram like reactions and hence should be avoided in patients who consume alcohol. Or the patient should stop alcohol consumption..

Metranidazole
Cephalosporins
Chlorpropamide
Furazolidine
Griseofulvin
Citrated calcium carbamide

Pharmacology »

[13 May 2012 | No Comment | ]

Certain drugs inhibit theophylline metabolism, thus increasing blood levels and cause toxicity:

Ciprofloxacin
Cimetidine
Erythromycin
Allopurinol
Oral contraceptives

Some others increase theophylline metabolism, decreasing blood levels:

Phenobarbitone
Phenytoin
Rifampicin

Smoking and consumption of charcoal boiled meat also increase theophylline metabolism.

Mock tests, Pharmacology »

[8 Jun 2011 | 3 Comments | ]

Questions summary:

All of the following are non selective beta blockers with additional actions except?
All of the following may be associated with beta 2 agonist treatment except?
True statement about clonidine are all except,
Finasteride is a:
Which of the following is not an alkylating agent?
Which of the following is a prodrug
All of the following are Gp IIb/Illa antagonist except?
Orange coloured urine is due to:
The drug having maximum propensity to cause peripheral neuropathy?
Nesiritide is a:

Pharmacology, Powerpoint presentations »

[24 Mar 2011 | No Comment | ]

Powerpoint presentation summary:

General considerations

Statistics
Important things to remember

Aspirin

Indications
Clinical presentation in aspirin overdose
Complications
Management of salicylism

Paracetamol

Clinical presentation
Use of IV N-acetylcysteine

Carbon monoxide

Mechanism of hypoxia
Use of hyperbaric oxygen in management

Cocaine poisoning
Opiates
3,4-methylenedioxy-methamphetamine - MDMA (Ecstasy)

Author : Kevin O’Shaughnessy
Download / View online

Pharmacology, Powerpoint presentations »

[11 Mar 2011 | One Comment | ]

Anticoagulants, Antiplatelet drugs and Thrombolytic agents – Presentation Summary

Major classes of drugs
Platelet Activation
Aspirin
Newer antiplatelets – Thienopyridines
CAPRIE trial
CURE trial
MATCH trial
Glycoprotein IIb/IIIa antagonists
Fibrinogenesis
Heparin – Mechanism of action
Features of Low Molecular Weight Heparin
LMWH vs Unfractionated heparin
Warfarin
Pharmacokinetics of warfarin
Drugs interactions of Warfarin
Warfarin toxicity treatment
Fibrinolysis
Tissue plasminogen activator vs streptokinase
Beyond LMWH
Ximelagatran

Download / View online

Pharmacology, Powerpoint presentations »

[11 Mar 2011 | No Comment | ]

Pharmacology of acute poisoning – Powerpoint Summary

General considerations
History
Investigations
Management

Decreasing poison absorption
Increasing poison elimination

Paracetamol – overdose and management
Aspirin – overdose and management
Tri cyclic antidepressants - overdose and management
Benzodiazepine - overdose and management
Poisoning by other drugs

Author : Dr Ian Wilkinson
Download / View online
 

Pharmacology »

[14 Jan 2011 | No Comment | ]

Teriparatide is a recombinant form of PTH that is used in patients with osteoporosis
The usual drugs used in osteoporosis are anti resorptive agents
But teriparatide has a unique mechanism of action
Endogenous PTH induces bone demineralisation
But intermittent pulses of exogenous PTH stimulates osteoblastic activity (Teriparatide is given once daily)
Teriparatide stimulates new bone formation – adds bone to periosteal surface and increases trabecular bone volume and connectivity

Reference:
Osteoporosis: a guide for clinicians By Pauline M. Camacho, Paul Miller

Pharmacology »

[13 Jan 2011 | No Comment | ]

The most important adverse effect of thalidomide is teratogenicity. The others include:

Peripheral neuropathy
Deep vein thrombosis
Constipation
Rash
Fatigue
Hypothyroidism

Reference:
Basic and Clinical Pharmacology, Katzung, 10th edition, p919