Alpha-2 adrenergic receptor – Location, Actions, Agonist, Antagonists

Location:

Prejunctional – adrenergic nerve endings
Post junctional – brain, pancreatic B cells
Extrajunctional – certain blood vessels, platelets

Actions:

Inbition of neurotransmitter release
Decreased central sympathetic outflow
Decreased insulin synthesis
Vasoconstriction
Platelet aggregation

Agonist – Clonidine

Antagonist – Yohimbine, Rauwolscine

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