Alpha-2 adrenergic receptor – Location, Actions, Agonist, Antagonists

Alpha-2 adrenergic receptor – Location, Actions, Agonist, Antagonists

Location:

  • Prejunctional – adrenergic nerve endings
  • Post junctional – brain, pancreatic B cells
  • Extrajunctional – certain blood vessels, platelets

Actions:

  • Inbition of neurotransmitter release
  • Decreased central sympathetic outflow
  • Decreased insulin synthesis
  • Vasoconstriction
  • Platelet aggregation

Agonist – Clonidine

Antagonist – Yohimbine, Rauwolscine

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