Factors responsible for malignant transformation in undescended testis

There is 40 times increased risk for malignant transformation in an undescended testis compared to testis located within the scrotum. The factors responsible for malignant transformation in undescended testis are:

  • Elevated temperature
  • Impairment of blood supply
  • Abnormal germ cell morphology
  • Endocrine dysfunction
  • Gonadal dysfunction

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