Features of multiple sclerosis – Medicine MCQ

Which of the following is false regarding Multiple Sclerosis (MS)?
A. More common in women and age of onset is between 20-40 years of age
B. Risk factors include vitamin D deficiency and cigarette smoking
C. Pathological hallmark is axonal degeneration
D. HLA DRB1 in MHC class II is associated with 10% of disease risk

Correct answer: C. Pathological hallmark is axonal degeneration


  • Multiple sclerosis is an auto immune disease of central neural system with a relapsing and remitting or progressive course.
  • The pathologic hallmark of disease is demyelination.
  • Myelin specific antibodies are present on degenerating myelin sheaths.
  • Surviving oligodendrocytes partially remyelinate surviving axons, which are called as shadow plaques.

Reference: Harrison’s Principles of Internal Medicine, 19th edition, p2661

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