Bart‘s hydrops fetalis is lethal because:
A. Hb Bart’s cannot bind oxygen
B. The excess alpha globin form insoluble precipitates
C. Hb Bart’s cannot release oxygen to fetal tssues
D. Microcytic red cells become trapped in the placenta
Correct answer : C. Hb Bart’s cannot release oxygen to fetal tssues
Hb Barts is formed of 4 gamma chains. The oxygen affinity is so high that it releases very little oxygen into the fetal tissues.