Paediatrics – MCQ 53 – Bart‘s hydrops fetalis

Bart‘s hydrops fetalis is lethal because:
A. Hb Bart’s cannot bind oxygen
B. The excess alpha globin form insoluble precipitates
C. Hb Bart’s cannot release oxygen to fetal tssues
D. Microcytic red cells become trapped in the placenta

Correct answer : C. Hb Bart’s cannot release oxygen to fetal tssues

Hb Barts is formed of 4 gamma chains. The oxygen affinity is so high that it releases very little oxygen into the fetal tissues.

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