Regression of clubbing can occur after corrective surgery for cyanotic congenital heart disease as they become acyanotic after surgery.
Regression of clubbing after treatment of lung cancer is well documented . Clubbing in infective endocarditis also regresses after successful treatment. Though regression of clubbing is a gradual process, faster than expected regression of clubbing within 3 days after mitral and aortic valve replacement for infective endocarditis has been reported .
Regression of clubbing after lung transplantation for cystic fibrosis usually occurred within a span of 3 months . To quantify the regression of clubbing, they measured the distal phalangeal depth (DPD) and interphalangeal depth (IPD) of index finger using skinfold caliper. The DPD/IPD was calculated and the ratio was found to be greater than 1 in all their 3 patients prior to lung transplantation. The ratio decreased to less than 1 in two of their patients within 3 months and within 9 months in the third patient.
1. Ciment AJ, Ciment L. Regression of Clubbing after Treatment of Lung Cancer. N Engl J Med. 2016 Sep 22;375(12):1171.
2. Ozdemir B, Sentürk T, Kaderli AA, Keçebaş M, Güllülü S, Baran I, Ozdabakoğlu O, Aydinlar A. Postoperative regression of clubbing at an unexpected rate in a patient with aortic and mitral valve replacement due to infective endocarditis. Ir J Med Sci. 2009 Sep;178(3):351-3.
3. Augarten A, Goldman R, Laufer J, Szeinberg A, Efrati O, Barak A, Miller MS, Yahav Y. Reversal of digital clubbing after lung transplantation in cystic fibrosis patients: a clue to the pathogenesis of clubbing. Pediatr Pulmonol. 2002 Nov;34(5):378-80.
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