Teriparatide – Mechanism of action
- Teriparatide is a recombinant form of PTH that is used in patients with osteoporosis
- The usual drugs used in osteoporosis are anti resorptive agents
- But teriparatide has a unique mechanism of action
- Endogenous PTH induces bone demineralisation
- But intermittent pulses of exogenous PTH stimulates osteoblastic activity (Teriparatide is given once daily)
- Teriparatide stimulates new bone formation – adds bone to periosteal surface and increases trabecular bone volume and connectivity
Reference:
Osteoporosis: a guide for clinicians By Pauline M. Camacho, Paul Miller