Triad of skin lesions, mononeuritis multiplex and eosinophilia – Medicine MCQ

Triad of skin lesions, asymmetric mononeuritis multiplex and eosinophilia are seen in?
A. Cryoglobulinemic vasculitis
B. Polyarteritis nodosa
C. Churg Strauss Syndrome
D. Giant cell arteritis

Correct answer : C. Churg Strauss Syndrome

Churg Strauss Syndrome

  • Churg Strauss Syndrome is a small vessel vasculitis.
  • Biopsy of affected site reveals small vessel vasculitis with eosinophilic infiltration of vessel wall.

Cryoglobulinemic vasculitis

  • Cryoglobulinemic vasculitis presents with rash over lower limbs, arthralgia, Raynaud’s phenomenon and neuropathy

Polyarteritis nodosa

  • Polyarteritis nodosa presents with fever, myalgia, arthralgia, multisystem involvement and palpable purpura.

Giant cell arteritis

  • Cardinal symptom of giant cell arteritis is headache localised to temporal or occipital region.
  • Visual disturbances can occur.
  • Catastrophic presentation is with blindness in one eye.
  • It is commonly associated with polymyalgia rheumatica.

Ref: Davidson’s Principles and Practice of Medicine, 22nd ed, p1117-1119