Use of sodium fluoride in otosclerosis – ENT MCQ

All are true regarding the use of sodium fluoride in otosclerosis except?
A. It inhibits proteolytic enzymes in the cochlea
B. It’s use is contraindicated in patients with chronic nephritis
C. It acts by inhibition of osteoblastic activity
D. It is used in patients with positive Schwartz sign

Correct answer : C. It acts by inhibition of osteoblastic activity

Use of sodium fluoride in otosclerosis

Mechanism of action

  • Sodium fluoride promotes osteoblastic activity and inhibits osteoclastic activity
  • This helps to decrease the bone remodelling taking place in the otosclerotic lesions and promotes recalcification
  • It also inhibits proteolytic enzymes in the cochlea and helps prevent sensorineural deafness

Indications

  • Progressive sensorineural hearing loss
  • Radiological evidence of a lesion
  • Positive Schwartz sign

Contraindications

  • Pregnancy / lactation
  • Fluoride allergy
  • Skeletal fluorosis
  • Children before completion of skeletal growth
  • Chronic rheumatoid arthritis
  • Chronic nephritis

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