Use of sodium fluoride in otosclerosis – ENT MCQ

All are true regarding the use of sodium fluoride in otosclerosis except?
A. It inhibits proteolytic enzymes in the cochlea
B. It’s use is contraindicated in patients with chronic nephritis
C. It acts by inhibition of osteoblastic activity
D. It is used in patients with positive Schwartz sign

Correct answer : C. It acts by inhibition of osteoblastic activity

Use of sodium fluoride in otosclerosis

Mechanism of action

Sodium fluoride promotes osteoblastic activity and inhibits osteoclastic activity
This helps to decrease the bone remodelling taking place in the otosclerotic lesions and promotes recalcification
It also inhibits proteolytic enzymes in the cochlea and helps prevent sensorineural deafness

Indications

Progressive sensorineural hearing loss
Radiological evidence of a lesion
Positive Schwartz sign

Contraindications

Pregnancy / lactation
Fluoride allergy
Skeletal fluorosis
Children before completion of skeletal growth
Chronic rheumatoid arthritis
Chronic nephritis

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