Drug causing vaginal carcinoma in female offspring – Pharmacology MCQ

Which is associated with vaginal carcinoma in female offspring?
A. Diethylstilbestrol
B. Phenytoin
C. ACE inhibitors
D. Indomethacin

Correct answer : A. Diethylstilbestrol

Chemical structure of Diethylstilbestrol

• Diethylstilbestrol can cause vaginal clear cell adenocarcinoma in girls and young women exposed to it in utero.
• Phenytoin can cause fetal hydantoin syndrome which is characterised by hypoplasia of the phalanges, cleft lip, cleft palate and microcephaly.
• Indomethacin / aspirin can cause premature closure of the ductus arteriosus.

Clear cell adenocarcinoma of ovary. Shown to illustrate characteristic clear cytoplasm rich in glycogen.

Ref: KDT 7th, p89
Image credits: Author: Nephron. Licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. http://en.wikipedia.org/wiki/File:Ovarian_clear_cell_carcinoma_-a-_very_high_mag_-_cropped.jpg