Absense of neutrophil response in bacterial vaginosis – Mechanism

  • Unlike other bacterial infections, bacterial vaginosis (BV) is not associated with an increase in the number of neutrophils in the vagnial fluid
  • The number of neutrophils may be normal or decreased
  • Gardnerella organisms do not induce neutrophil chemotaxis
  • The exact mechanism is not known
  • Certain BV associated factors specifically prevent the rise in Interleukin 8 (IL-8) levels which is necessary for neutrophil chemotaxis

Ref : Mucosal immunology By Jiri Mestecky

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