Statins are usually taken before going to sleep. This is because the hepatic synthetic activity is maximum at night. Hence statins have maximum efficiency in decreasing cholesterol when
Warfarin exerts its anticoagulant action by interfering with the vitamin K mediated synthesis of clotting factors in the liver. Hepatic synthetic function is maximum at night. So warfarin
Hutchinson's pupil is seen in case of cerebral compression. There are 3 stages. Mechanism: The parasympathetic fibers to the pupil are responsible for pupillary constriction. The fibers pass
5% dextrose is a free water solution. Dextrose gets metabolised and plasma osmolality is decreased. This increases the brain oedema in head injury and hence should be avoided.
Cockcroft-Gault formula is used to estimate creatinine clearance rate using age, weight and serum creatinine level. It is named after the scientists who created the formula. eCcr =
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