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Dimercaprol – British anti lewisite (BAL)

Dimercaprol, also known as British anti lewisite (BAL) is a chelating agent used in the treatment of heavy metal poising (those which act by inhibiting the SH group

Pharmacology

Leuprolide and flutamide

Leuprolide is a superactive GnRH (Gonadotropin releasing hormone) agonist. It can be given with flutamide for prostate cancer. Gonadotropin secretion occurs due to pulsatile secretion of GnRH. But when

Pharmacology

Ethinyl estradiol and norgestrel

Ethinyl estradiol and norgestrel are a combination of drugs used as hormonal contraceptive in women. Ethinyl estradiol is synthetic estrogen analogue and norgestrel is a synthetic progesterone analogue. Mechanism of action

Pharmacology

Linezolid

Linezolid is an oxazolidinone antimicrobial agent. It is a bacteriostatic agent. Spectrum of action MRSA (Methicillin resistant Staphylococcus areus), some VRSA (Vancomycin resistant Staphylococcus areus), VRE (Vancomycin resistant enterococci), Streptococcus

Pharmacology

Urinary antiseptics

Urinary antiseptics are antimicrobial agents. When these are given in orally tolerated doses, they attain antibacterial concentrations only in urine due to concentration in the renal tubules. These

Pharmacology

Isoniazid and pyridoxine

Isoniazid is an antituberculous drug. It can cause peripheral neuropathy and rarely convulsions by decreasing the availability of pyridoxine (vitamin B6). Isoniazid binds to pyridoxal-5-phosphate, the active form

Pharmacology

Amoxycillin and clavulanic acid (Co-amoxyclav)

Amoxycillin is an extended spectrum aminopenicillin. But it is not active against penicillinase producing organism. Clavulanic acid is a penicillinase inhibitor which initially reversibly and then irreversibly inhibits

Pharmacology

Classification of oral hypoglycemic agents

Sulphonyl ureas – first generation (tolbutamide, chlorpropamide); second generation – (glibenglamide, glipizide, gliclazide, glimiperide) Biguanides – metformin Meglitinides – repaglinide, nateglinide Thiazolidine diones – rosiglitazone, pioglitazone Alpha glucosidase

Pharmacology

Glibenclamide

Glibenclamide is an oral hypoglycemic drug belonging to the group sulphonyl ureas. It is a second generation sulphonyl urea. Other sulphonyl ureas include – glipizide, gliclazide and glimiperide.